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Ngaso sonke isikhathi uma i-batch iphakanyiswa ngenxa yokuthi i-solvent ayihlangabezani nencazelo, othile kufanele achaze ukuthi kungani. Lolo hlobo lokuphazamiseka luyengeza - ngesikhathi sokuhlola, ukuthunyelwa okubambezelekile futhi kwesinye isikhathi ekulungisweni kwenqubo okungakaze kube yingxenye yohlelo lwangempela. E-Dotachem, lesi yisimo esizwa ngaso kumakhasimende kaningi kunalokho ongakulindela.
I-I-Dimethylformamide(DMF)ngokuvamile kuvela kulezi zingxoxo. Eyaziwa nangokuthi i-N,N-Dimethylformamide ene-CAS No. 68-12-2, i-DMF iyi-solvent ye-polar aprotic esetshenziswa ezinqubweni eziningi ezinhle zokuhlanganisa amakhemikhali kanye nemithi. Incibilikisa izinto ezinye izincibilikisi ezilwa nazo, ihlala izinzile ngaphansi kwezimo eziningi zokusabela, futhi ixubana kahle namanzi nezincibilizi ezihlukahlukene eziphilayo. Le nhlanganisela yenza kube nzima ukushintshwa emizileni ethile yokuhlanganisa.
Ekuhlanganiseni kwamakhemikhali aphakathi nendawo nakahle, i-DMF ingasetshenziswa ezinhlelweni zokusabela lapho ukukhetha kwe-solvent kungathinta ukusebenza kahle kokusabela, ukulawula ukungcola kanye nokuzinza kwenqubo. Ukusabela kokuhlanganisa i-Peptide, ukwakheka kwebhondi ye-amide kanye nokusabela okuthile kokushintsha kwe-nucleophilic kuyizibonelo ezivamile lapho kucatshangelwa khona izinyibilikisi ze-polar aprotic ezifana ne-DMF. Iphoyinti layo lokubilisa eliphakeme uma kuqhathaniswa livumela ukusabela okuthile ukuthi kusebenze kumazinga okushisa aphakeme ngaphandle kokulahlekelwa kwencibiliki ngokushesha.
Emizileni yokuhlanganiswa kwezinyathelo eziningi, ukusebenza kwe-solvent akukhona nje ukuhlakaza into yokuqala. Isinyibilikisi esifanelekile singasiza ukugcina abaphakathi esixazululweni kuzo zonke izigaba zokusabela ezihlukene, ukunciphisa ukuphazamiseka kwenqubo okungadingekile futhi basekele ukulawulwa kokukhiqiza okungabikezelwa okwengeziwe. Yingakho abathengi abaningi bephatha ukungaguquguquki kwe-DMF njengengxenye yengozi yokukhiqiza iyonke, hhayi nje njengemininingwane yokuthenga.
Ukungaguquguquki kwe-solvent ngokuvamile kubaluleke kakhulu kunalokho okubonakala kuqala. Ukwehluka kwe-batch-to-batch emswakameni, umbala noma umkhondo wokungcola kungadala umsebenzi wokuhlola owengeziwe, amandla okukhiqiza angaba khona noma ukulungiswa kwenqubo ngaphambi kokuqhubeka okulandelayo. Ngalesi sizathu, abathengi bavame ukugxila ekuzinzeni kwencazelo nokuthembeka kwabahlinzeki, hhayi nje inani.
Ekuxhumaneni okusebenzayo kokuthola usizo, amakhasimende afuna i-DMF yezicelo zamakhemikhali aphakathi nendawo noma amahle ngokuvamile abuza ngobumsulwa, umswakama, i-acidity noma i-alkalinity, ukubukeka, imibhalo etholakalayo kanye nesikhathi sokuhola sokuthunyelwa. Iningi lale mibuzo lifika ekukhathazeni okukodwa: ingabe le nto izodala izinkinga ohlelweni lwami?
Njengoba abathengi abaningi nabahlinzeki bempahla behlangana emibukisweni yemboni yezemithi efana ne-CPHI, izingxoxo mayelana nokutholakala kwe-solvent sezisebenziseka kakhulu. Abathengi abaqhathanisi kuphela amagama emikhiqizo noma izingcaphuno. Baphinde babheke abahlinzeki abanganikeza imibhalo ecacile, ukuxhumana okuzinzile kwekhwalithi nokusekelwa okufika ngesikhathi lapho amashejuli okukhiqiza eshintsha.
Njengomphakeli wamakhemikhali ozinze e-China, i-Dotachem ihlinzeka nge-Dimethylformamide (DMF) yokukhiqiza izimboni, ukuhlanganiswa kwemithi okumaphakathi kanye nokusetshenziswa kwamakhemikhali amahle. Sisekela amakhasimende ngokuqinisekiswa okucacisiwe, ukuhlolwa kwekhwalithi, i-COA, i-TDS, i-SDS kanye nemibhalo yokuthekelisa ngokwezidingo ze-oda. Kumakhasimende adinga ukunikezwa okuphindaphindiwe, ithimba lethu lingasiza futhi ngokuxhumana nokupakisha, ukuhlela ukuthunyelwa kanye nokusekelwa kokufuna isikhathi eside.
Ngaphandle kwe-DMF, i-Dotachem iphinde isekele amakhasimende ngezinto ezisetshenziswayo ezingavuthiwe zamakhemikhali kanye neziphakathi, njengeI-I-Monoethanolamine(MEA),I-I-Diethanolamine(DEA),I-I-Ethylenediamine(EDA),I-Glacial Acrylic Acid(GAA), Methyl Methacrylate, Methacrylic Acid,I-I-Nonylphenolkanye ne-PTBP. Le mikhiqizo ingakwazi ukusekela izidingo ezibanzi zokuthola usizo kuma-intermediate emithi, ukuhlanganiswa kwamakhemikhali, okokunamathela, ama-resin, ama-polymers kanye nezinhlelo zokwakhiwa kwezimboni.
Uma ufuna i-DMF noma izinto zokusetshenziswa zamakhemikhali ezihlobene nezicelo zamakhemikhali eziphakathi nendawo noma ezinhle,othintana nayeI-Dotachem yokucaciswa komkhiqizo, imibhalo kanye nokwesekwa kokuhlinzekwa okuvela e-China.
